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After the initial assessment, participants 2. We thank the participants in the trial for their enthusiastic and sustained collaboration and Joan Vila from Institut Municipal d'Investigació Studio de ensaio, Barcelona, for expert assessment in the statistical analyses.

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The lower intensity of dietary intervention for the control group during the first few years might have caused a bias toward a benefit studio de ensaio the two Mediterranean-diet groups, since the participants enwaio these two groups received a more intensive intervention during that time.

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Address reprint requests to Dr. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet.

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Yearly interim analyses began after a median of 2 years of follow-up. We conducted a randomized trial of this diet pattern for the primary prevention of cardiovascular events.

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Reduction in the incidence of type 2 diabetes with the Mediterranean diet: The main nutrient changes in the Mediterranean-diet groups reflected the fat content and composition of the supplemental studio de ensaio Tables S7 and S8 in the Supplementary Appendix.

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The unadjusted hazard ratios were 0. However, favorable trends were seen for both stroke and myocardial infarction.

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The Kaplan—Meier curves for the primary end studio de ensaio diverged soon after the trial started, but no effect ensaik all-cause mortality was apparent Figure 1. Consultório no Leblon Leblon - RJ.

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Participants in the two Mediterranean-diet groups studio de ensaio increased weekly servings of dd by 0. Artigos academicos exemplos in disease risk in the two Mediterranean-diet groups as compared with the control group were similar across the prespecified subgroups Figure 2and Table S10 in the Supplementary Appendix.

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Adherence to Mediterranean diet and risk of developing diabetes:

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Changes in objective biomarkers also indicated good compliance with the dietary assignments Fig.

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Arch Intern Med ; Methods In a multicenter trial in Spain, we randomly assigned participants who were at high cardiovascular studio de ensaio, but with no cardiovascular disease at enrollment, to one of three diets:

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Regarding components of the primary end point, only the comparisons of stroke risk reached statistical significance Table 3and Fig.

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Nuts and berries for heart health.

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However, the realization that the more infrequent visit schedule and less intense support for the control group might be limitations of the trial prompted us to amend the protocol in October Major outcomes studio de ensaio moderately hypercholesterolemic, hypertensive patients ensaaio to pravastatin vs usual care:

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Among persons at high cardiovascular risk, a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced the incidence of major cardiovascular events.

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On the basis of the results of an interim analysis, the trial was stopped after a median follow-up of 4.

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Consultório Nova Iguaçu - RJ.

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Scores for adherence to the Mediterranean diet range from 0 to 14, with higher scores indicating greater adherence.

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Nunc ut sem vitae risus tristique posuere. On the basis of the results of an interim analysis, the trial was stopped after a median follow-up of 4.

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Outcomes According to Study Group. Our study has several limitations.

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Effect of a traditional Mediterranean diet on lipoprotein oxidation: Consultório médico Recreio - RJ. The authors vouch for the accuracy and completeness of the data and all analyses and for the fidelity of this report to the protocol , which is available with the full text of this article at NEJM. Sensitivity analyses were conducted under several assumptions, including imputation of data for missing values and participants who dropped out see the Supplementary Appendix.

Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. The risk of stroke was reduced significantly in the two Mediterranean-diet groups. All medical records related to end points were examined by the end-point adjudication committee, whose members were unaware of the study-group assignments. Outcomes According to Study Group. The lower intensity of dietary intervention for the control group during the first few years might have caused a bias toward a benefit in the two Mediterranean-diet groups, since the participants in these two groups received a more intensive intervention during that time.

However, we found no significant interaction between the period of trial enrollment before vs. Disclosure forms provided by the authors are available with the full text of this article at NEJM. No diet-related adverse effects were reported. Participants in the two Mediterranean-diet groups significantly increased weekly servings of fish by 0. The interventions were intended to improve the overall dietary pattern, but the major between-group differences involved the supplemental items.

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